Diabetic ketoacidosis and clozapine.
نویسندگان
چکیده
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منابع مشابه
Stable monotherapy with clozapine or olanzapine increases the incidence of diabetes mellitus in people with schizophrenia.
Risk factors: Participants diagnosed with diabetes mellitus or hospitalised with diabetic ketoacidosis were identified from the Department of Veterans Affairs and were predominantly older and male. Time to diagnosis and hospitalisation was modelled using the Cox proportional hazards models. Attributable risks of each outcome associated with different antipsychotics were calculated. The five ant...
متن کاملDiabetic ketoacidosis associated with atypical antipsychotic drug, clozapine treatment: Report of a case and review of literature
A b st ra ct Atypical antipsychotic drugs are associated with metabolic disturbances like weight gain, type 2 diabetes hyperglycaemia and dyslipedemia, which can result in serious health risk in patients. Diabetic ketoacidosis resulting in serious metabolic acidosis, occurring in a schizophrenic patient on treatment with clozapine is being reported to draw attention this association. Frequent m...
متن کاملDiabetic ketoacidosis and severe hypertriglyceridaemia as a consequence of an atypical antipsychotic agent.
The atypical antipsychotic agent clozapine, although an effective treatment for schizophrenia, is linked with metabolic adverse effects. We report a case of diabetic ketoacidosis and very severe hypertriglyceridaemia associated with clozapine use, in a patient with type 2 diabetes mellitus, who was successfully treated with continuous insulin infusion and fluids. As clozapine proved to be the m...
متن کاملDiabetes mellitus associated with atypical antipsychotic medications: new case report and review of the literature.
BACKGROUND Since the introduction of atypical antipsychotic medications, beginning with clozapine in 1990, several case reports in the psychiatric literature have suggested that they might be associated with new onset of diabetes mellitus as well as with diabetic ketoacidosis. METHODS We report the case of a 38-year-old patient with schizophrenia who suddenly developed diabetes mellitus and k...
متن کاملDiabetic ketoacidosis associated with antipsychotic drugs: case reports and a review of literature.
BACKGROUND Second generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation linked to the use of SGAs. The aims of this article are to present patients with a history of psychotic disorders and of severe metabolic diabetic ketoacidosis, possibly associated with the use ...
متن کاملRhabdomyolysis in Clozapine Overdose
CONTEXT Clozapine is used for decennia for the treatment of schizophrenia. Agranulocytosis, diabetic ketoacidosis, gastrointestinal hypomotility, and myocarditis are well-known adverse effects of clozapine, which are sometimes life threatening. Here we report a case of rhabdomyolysis upon an acute overdose of clozapine. CASE A male patient, 36 years, with elevated creatinine kinase levels (98...
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 74 874 شماره
صفحات -
تاریخ انتشار 1998